Descritores: Adenoma hipofisário produtor de glicoproteína; Adenoma .. esses fatores de crescimento possam ter algum papel na tumorigênese pituitária (56). tratamento primário realizado nos pacientes com adenomas não-fun- . cirurgia de um adenoma hipofisário, por exemplo, a pres- .. 3. Pituitary adenomas are tumors that occur in the pituitary gland. Pituitary adenomas are .. "Magnetic resonance spectroscopy in pituitary tuberculoma" ( PDF).

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Adenoma de hipófise ou de pituitária é um tumor não-maligno que ocorre na hipófise. . Criar um livro · Descarregar como PDF · Versão para impressão. expressão dos genes Notch3 e Jagged1 em adenomas de hipófise, fornecendo indícios Os adenomas hipofisários são um grupo diverso de tumores que tem. ΔNp63) e proteica do p63 está diminuída nos adenomas de hipófise. Palavras- chave: Células tronco tumorais, adenomas hipofisários, pluripotência, tumores.

Challenges and pitfalls in the diagnosis of hyperprolactinemia. Arq Bras Endocrinol Metab. Prevalence of hyperprolactinemia and abnormal magnetic resonance imaging findings in a population with infertility.

Prolactin: Structure, Function, and Regulation of Secretion. Physiol Rev. Fitzgerald P, Dinan TG. Prolactin and dopamine: What is the connection?

A Review Article. J Psychopharmacol. Prolactin actions.

Pituitary adenoma

J Mol Endocrinol. New insights in prolactin: pathological implications. Nat Rev Endocrinol. A pathway map of prolactin signaling. J Cell Commun Signal. Kaiser UB. Hyperprolactinemia and infertility: New insights. J Clin Invest. Hunag W, Molitch ME. Evaluation and Management of Galactorrhea.

Am Fam Physician. Importance of cannulated prolactin test in the definition of hyperprolactinaemia.


Pituitary Tumor Management in Pregnancy. Endocrinol Nutr. Hyperprolactinaemia: Psychological aspects and menstrual attitudes of women with schizophrenia. Hyperprolactinemia and medications for bipolar disorder: Systematic review of a neglected issue in clinical practice.

Eur Neuropsychopharmacol. Drug-induced hypo- and hyperprolactinemia: mechanisms, clinical and therapeutic consequences. Expert Opin Drug Metab Toxicol. Adjunctive treatment with aripiprazole for risperidone-induced hyperprolactinemia. Neuropsychiatr Dis Treat.

BMC Psychiatry. The natural history of macroprolactinaemia. Eur J Endocrinol.

Inflammatory and granulomatous expansive lesions of the pituitary. Makras P, Kaltsas G. Langerhans cell histiocytosis and pituitary function. Hypothalamo-pituitary sarcoidosis: a multicenter study of 24 patients.

Q J Med. Pituitary involvement in granulomatosis with polyangiitis: report of 9 patients and review of the literature. Pituitary metastasis presenting as diabetes insipidus: A report of four cases and literature review. Rev Med Interne. Arch Med Res. Holley JL.

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The hypothalamic-pituitary axis in men and women with chronic kidney disease. Adv Chornic Kidney Dis. Horm Metab Res. It may also result in various cognitive difficulties. Hyperpituitarism is a disease of the anterior lobe of the pituitary gland which is usually caused by a functional pituitary adenoma and results in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone; and adrenocorticotropic hormone.

Pituitary apoplexy is a condition that occurs when pituitary adenomas suddenly hemorrhage internally, causing a rapid increase in size or when the tumor outgrows its blood supply which causes tissue necrosis and subsequent swelling of the dead tissue. Pituitary apoplexy often presents with visual loss and sudden onset headache and requires timely treatment often with corticosteroids and if necessary surgical intervention.

Vasopressin is produced in the hypothalamus and is then transported down the pituitary stalk and stored in the posterior lobe of the pituitary gland which then secretes it into the bloodstream.

Pituitary adenoma

As the pituitary gland is in close proximity to the brain, invasive adenomas may invade the dura mater , cranial bone , or sphenoid bone.

MEN causes various combinations of benign or malignant tumors in various glands in the endocrine system or may cause the glands to become enlarged without forming tumors. It often affects the parathyroid glands , pancreatic islet cells, and anterior lobe of the pituitary gland.

MEN1 may also cause non-endocrine tumors such as facial angiofibromas , collagenomas , lipomas , meningiomas , ependymomas , and leiomyomas. Approximately 25 percent of patients with MEN1 develop pituitary adenomas. There are however no isolated prolactinomas or any other type of pituitary tumor. In some patients with CNC, the pituitary gland is characterized by hyperplastic areas with the hyperplasia most likely preceding the formation of GH-producing adenomas.

Daly and colleagues showed that acromegaly cases with AIP mutations occurred about 20 years before acromegaly cases without AIP mutations and these tumors are large and relatively treatment resistant.

Part of the hypothalamic-pituitary axis , it controls most of the body's endocrine functions via the secretion of various hormones into the circulatory system. The pituitary gland is located below the brain in a depression fossa of the sphenoid bone known as the sella turcica.

Although anatomically and functionally connected to the brain, the pituitary gland [37] sits outside the blood—brain barrier. It is separated from the subarachnoid space by the diaphragma sella , therefore the arachnoid mater and thus cerebral spinal fluid cannot enter the sella turcica.

The pituitary gland is divided into two lobes, the anterior lobe which accounts for two thirds of the volume of the gland , and the posterior lobe one third of the volume separated by the pars intermedia. The posterior lobe the neural lobe or neurohypophysis of the pituitary gland is not, despite its name, a true gland.

The posterior lobe contains axons of neurons that extend from the hypothalamus to which it is connected via the pituitary stalk. The hormones vasopressin and oxytocin , produced by the neurons of the supraoptic and paraventricular nuclei of the hypothalamus, are stored in the posterior lobe and released from axon endings dendrites within the lobe. The differential diagnosis includes pituitary tuberculoma, especially in developing countries and in immumocompromised patients.

Classification[ edit ] Unlike tumors of the posterior Pituitary, Pituitary adenomas are classified as endocrine tumors not brain tumors. Pituitary adenomas are classified based upon anatomical , histological and functional criteria.

Stage III: macroadenomas with enlargement and invasion of the floor or suprasellar extension. Stage IV is destruction of the sella.Pituitary adenomas are classified based upon anatomical , histological and functional criteria. Therefore a reoperation was planned to remove the residual tumor and seal the CSF fistula.

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Prolactin actions. Safety of long-term treatment with cabergoline on cardiac valve disease in patients with prolactinomas. Histological classification utilizes an immunohistological characterization of the tumors in terms of their hormone production.

There are however no isolated prolactinomas or any other type of pituitary tumor. Mahler, et al. Figure 1. Acromegaly is a syndrome that results when the anterior pituitary gland produces excess growth hormone GH.

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